Article
Resistance in pediatric patients experiencing virologic failure with first-line and second-line antiretroviral therapy.
The Pediatric infectious disease journal - 1 Jun 2013
Orrell Catherine, Levison Julie, Ciaranello Andrea, Bekker Linda-Gail, Kuritzkes Daniel R, Freedberg Kenneth A, Wood Robin
Abstract excerpt
We examined HIV-1 resistance in children failing first-line and second-line antiretroviral therapy in South Africa, all with clade C virus. Those exposed to full-dose ritonavir had multiple protease resistance mutations. Nineteen percent had wild-type virus. Appropriate antiretroviral therapy sequencing in sub-Saharan African children is essential for prolong treatment options.
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