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Article

Initiation of tRNA maturation by RNase E is essential for cell viability in E. coli.

Genes & development - 1 May 2002

Ow Maria C, Kushner Sidney R

Abstract excerpt

RNase E, an essential endoribonuclease in Escherichia coli, is involved in 9S rRNA processing, the degradation of many mRNAs, and the processing of the M1 RNA subunit of RNase P. However, the reason that RNase E is required for cell viability is still not fully understood. In fact, recent experiments have suggested that defects in 9S rRNA processing and mRNA decay are not responsible for the lack of cell growth...

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Identifiers

PMID: 12000793
DOI: 10.1101/gad.983502
PMCID: PMC186257

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Initiation of tRNA maturation by RNase E is essential for cell viability in E. coli.PMID 12000793Read ↗

Ribonuclease P processes polycistronic tRNA transcripts in Escherichia coli independent of ribonuclease E.Semantic proximity Read ↗

The function of RNase G in Escherichia coli is constrained by its amino and carboxyl termini.Semantic proximity Read ↗

RNase G of Escherichia coli exhibits only limited functional overlap with its essential homologue, RNase E.Semantic proximity Read ↗

Generation of pre-tRNAs from polycistronic operons is the essential function of RNase P in Escherichia coli.Semantic proximity Read ↗

Decreased Expression of Stable RNA Can Alleviate the Lethality Associated with RNase E Deficiency in Escherichia coli.Semantic proximity Read ↗

Intragenic suppressors of temperature-sensitive rne mutations lead to the dissociation of RNase E activity on mRNA and tRNA substrates in Escherichia coli.Semantic proximity Read ↗

Processing of the seven valine tRNAs in Escherichia coli involves novel features of RNase P.Semantic proximity Read ↗

Maturation of precursor 10Sa RNA in Escherichia coli is a two-step process: the first reaction is catalyzed by RNase III in presence of Mn2+.Semantic proximity Read ↗

Enzymatic activity necessary to restore the lethality due to Escherichia coli RNase E deficiency is distributed among bacteria lacking RNase E homologues.Semantic proximity Read ↗

Processing of m1 RNA at the 3' end protects its primary transcript from degradation.Semantic proximity Read ↗

Structural requirements for the processing of Escherichia coli 5 S ribosomal RNA by RNase E in vitro.Semantic proximity Read ↗

RNase E, an endoribonuclease, has a general role in the chemical decay of Escherichia coli mRNA: evidence that rne and ams are the same genetic locus.Semantic proximity Read ↗

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