Article
The T-box repressors TBX2 and TBX3 specifically regulate the tumor suppressor gene p14ARF via a variant T-site in the initiator.
The Journal of biological chemistry - 19 Jul 2002
Lingbeek Merel E, Jacobs Jacqueline J L, van Lohuizen Maarten
Abstract excerpt
The murine tumor suppressor p19(ARF) (p14(ARF) in humans) is thought to fulfill an important protective role in preventing primary cells from oncogenic transformation via its action in the p53 pathway. Several disease-implicated regulators of p19(ARF) are known to date, among which are the T-box...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- COS Cells
- Cell Transformation, Neoplastic
- Codon, Initiator
- DNA
- Dimerization
- Fetal Proteins
- Genes, p16
- Humans
- Mice
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Sequence Deletion
- T-Box Domain Proteins