Article
Fierce: a new mouse deletion of Nr2e1; violent behaviour and ocular abnormalities are background-dependent.
Behavioural brain research - 14 May 2002
Young Kelly A, Berry Melissa L, Mahaffey Connie L, Saionz Jennifer R, Hawes Norman L, Chang Bo, Zheng Qing Yin, Smith Richard S, Bronson Roderick T, Nelson Randy J, Simpson Elizabeth M
Abstract excerpt
A new spontaneous mouse mutation named fierce (frc) is deleted for the nuclear receptor Nr2e1 gene (also known as Tlx, mouse homolog of Drosophila tailless). The fierce mutation is genetically and phenotypically similar to Nr2e1 targeted mutations previously studied on segregating genetic backgrounds. However, we have characterized the fierce brain, eye, and behavioural phenotypes on three defined genetic...
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