Article
"Sighted C3H" mice--a tool for analysing the influence of vision on mouse behaviour?
Frontiers in bioscience : a journal and virtual library - 1 May 2008
Hoelter Sabine M, Dalke Claudia, Kallnik Magdalena, Becker Lore, Horsch Marion, Schrewe Anja, Favor Jack, Klopstock Thomas, Beckers Johannes, Ivandic Boris, Gailus-Durner Valérie, Fuchs Helmut, Hrabé de Angelis Martin, Graw Jochen, Wurst Wolfgang
Abstract excerpt
It is unclear what role vision plays in guiding mouse behaviour, since the mouse eye is of comparably low optical quality, and mice are considered to rely primarily on other senses. All C3H substrains are homozygous for the Pde6b(rd1) mutation and get blind by weaning age. To study the impact of the Pde6b(rd1) mutation on mouse behaviour and physiology, sighted C3H (C3H.Pde6b+) and normal C3H/HeH mice were...
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