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Article

Pathological aggression in "fierce" mice corrected by human nuclear receptor 2E1.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 6 Jul 2005

Abrahams Brett S, Kwok Melvin C H, Trinh Eric, Budaghzadeh Saeed, Hossain Sazzad M, Simpson Elizabeth M

Abstract excerpt

"Fierce" mice, homozygous for the deletion of nuclear receptor 2E1 (NR2E1), show abnormal brain-eye development and pathological aggression. To evaluate functional equivalency between mouse and human NR2E1, we generated mice transgenic for a genomic clone spanning the human NR2E1 locus and bred these animals to fierce mice deleted for the corresponding mouse gene. In fierce mutants carrying human NR2E1,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16000615
DOI: 10.1523/JNEUROSCI.4757-04.2005
PMCID: PMC6725287

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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