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Article

Are cytochrome b gene mutations the only cause of atovaquone resistance in Pneumocystis?

Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy - 1 Oct 2001

Kaneshiro E S

Abstract excerpt

There is evidence that exposure of the opportunistic pathogen Pneumocystis to atovaquone enhances the development of resistance to the drug. Atovaquone is a structural analog of ubiquinone, which binds to the mitochondrial cytochrome bc(1) complex and inhibits electron transport. Like the parasites Plasmodium and Toxoplasma, atovaquone resistance can result from mutations in the cytochrome b gene of Pneumocystis....

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Identifiers

PMID: 11991686
DOI: 10.1054/drup.2001.0221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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