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Article

Sequence Polymorphisms in the<i>Pneumocystis carinii</i>Cytochrome<i>b</i>Gene and Their Association with Atovaquone Prophylaxis Failure

1 Dec 1998

Abstract excerpt

Atovaquone (Mepron, 566c80) is an effective agent against Pneumocystis carinii, which probably acts by binding to cytochrome b and inhibiting electron transport. To assess the possibility that atovaquone resistance might be developing, the genes for the cytochrome b from P. carinii sp. f. carinii and P. carinii sp. f. hominis were partially sequenced. Eight of 10 patient isolates had cytochrome b genes with the...

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PMID: 9815231
DOI: 10.1086/314509

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