Article
Atovaquone exposure and Pneumocystis jirovecii cytochrome b mutations: French data and review of the literature.
Medical mycology - 4 Sept 2023
Bonnet Pierre L, Hoffmann Claire V, Le Nan Nathan, Bellamy Lorenn, Hoarau Gautier, Flori Pierre, Demar Magalie, Argy Nicolas, Morio Florent, Le Gal Solène, Nevez Gilles
Abstract excerpt
Pneumocystis jirovecii is a transmissible fungus responsible for severe pneumonia (Pneumocystis pneumonia [PCP]) in immunocompromised patients. Missense mutations due to atovaquone selective pressure have been identified on cytochrome b (CYB) gene of P. jirovecii. It was recently shown that atovaquone prophylaxis can lead to the selection of specific P. jirovecii CYB mutants potentially resistant to atovaquone...
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