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Pneumocystis Cytochrome b Mutants Associated With Atovaquone Prophylaxis Failure as the Cause of Pneumocystis Infection Outbreak Among Heart Transplant Recipients.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 31 Aug 2018

Argy Nicolas, Le Gal Solène, Coppée Romain, Song Zehua, Vindrios William, Massias Laurent, Kao Wei-Chun, Hunte Carola, Yazdanpanah Yazdan, Lucet Jean-Christophe, Houzé Sandrine, Clain Jérôme, Nevez Gilles

Abstract excerpt

Background: Although trimethoprim-sulfamethoxazole is the more efficient drug for prophylactic and curative treatment of pneumocystosis, atovaquone is considered a second-line prophylactic treatment in immunocompromised patients. Variations in atovaquone absorption and mutant fungi selection after atovaquone exposure have been associated with atovaquone prophylactic failure. We report here a Pneumocystis...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29514207
DOI: 10.1093/cid/ciy154

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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