Article
Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population.
European journal of endocrinology - 1 May 2002
Malecki Maciej T, Moczulski Dariusz K, Klupa Tomasz, Wanic Krzysztof, Cyganek Katarzyna, Frey Jakub, Sieradzki Jacek
Abstract excerpt
OBJECTIVE: The polymorphisms of two genes have recently been associated with complex forms of type 2 diabetes mellitus (T2DM): calpain 10 and peroxisome proliferator-activated receptor-gamma (PPARgamma). Calpain 10 is a member of a large family of intracellular proteases. It was shown in Mexican-Americans and other populations that variants of three single nucleotide polymorphisms (SNPs), -43, -19, and -63, of...
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