Article

The ABL-BCR fusion gene is expressed in chronic myeloid leukemia

1993-01-01

Abstract excerpt

Abstract Although the BCR-ABL hybrid gene on chromosome 22q-plays a pivotal role in the pathogenesis of chronic myeloid leukemia (CML), little is known of the reciprocal chimeric gene, ABL-BCR, formed on chromosome 9q+. By reverse transcription/polymerase chain reaction amplification (RT/PCR) we have detected ABL-BCR mRNA in cells from 31 of 44 BCR-ABL positive CML patients and 3 of 5 CML cell lines. Of the 34 pos...

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Literature Corpus work: 316931cb-4ec9-527a-a8d0-3cc063dd3b4b
DOI: 10.1182/blood.v81.1.158.158

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