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Article

Central MHC genes affect IgA levels in the human: reciprocal effects in IgA deficiency and IgA nephropathy.

Human immunology - 1 May 2002

Matthews Vance B, Witt Campbell S, French Martyn A H, Machulla Helmut K G, De la Concha Emilio G, Cheong Karey Y, Vigil Patricia, Hollingsworth Peter N, Warr Kevin J, Christiansen Frank T, Price Patricia

Abstract excerpt

This study investigates the hypothesis that alternative alleles of one or more genes in the central major histocompatibility complex (MHC) predispose carriers to IgA deficiency (IgAD) or IgA Nephropathy (IgAN). Australian caucasian IgAD, IgAN patients, and controls were typed at HLA loci, single nucleotide polymorphisms, and microsatellites in the MHC. Alleles of the D6S273 microsatellite exhibited strong...

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Share to Glomerulonephritis, IGA
Share to HLA-B8 Antigen

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11975987
DOI: 10.1016/s0198-8859(02)00383-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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