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Article

Epistatic effects occurring among susceptibility and protective MHC genes in IgA deficiency.

Genes and immunity - 1 Jun 2003

Martínez A, Gual L, Fernández-Arquero M, Nogales A, Ferreira A, Garcia-Rodriguez M C, Fontan G, de la Concha Ed E G

Abstract excerpt

Immunoglobulin A deficiency (IgAD), the most prevalent primary immunodeficiency in Caucasian populations, shows strong evidence of polygenic inheritance with several associated genes being located in the major histocompatibility complex (MHC). Our aims were to determine which previously described MHC associations were primary and not secondary to a decrease or an increase in other MHC haplotype frequencies, to...

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PMID: 12761569
DOI: 10.1038/sj.gene.6363955

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RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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