Article
Mutations in fd phage major coat protein modulate affinity of the displayed peptide.
Protein engineering, design & selection : PEDS - 1 Oct 2009
Kuzmicheva G A, Jayanna P K, Eroshkin A M, Grishina M A, Pereyaslavskaya E S, Potemkin V A, Petrenko V A
Abstract excerpt
Multibillion-clone libraries of phages displaying guest peptides fused to the major coat protein pVIII (landscape libraries) are a rich source of probes for proteinaceous and non-proteinaceous targets. As opposed to the pIII-type fusion phages, which display peptides as independent structural domains, the guest peptides in the pVIII-fusion phages can be structurally and functionally influenced by contiguous...
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