Article
Somatic hypermutation of the new antigen receptor gene (NAR) in the nurse shark does not generate the repertoire: possible role in antigen-driven reactions in the absence of germinal centers.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 1998
Diaz M, Greenberg A S, Flajnik M F
Abstract excerpt
The new antigen receptor (NAR) gene in the nurse shark diversifies extensively by somatic hypermutation. It is not known, however, whether NAR somatic hypermutation generates the primary repertoire (like in the sheep) or rather is used in antigen-driven immune responses. To address this issue, th...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Cloning, Molecular
- DNA Primers
- Immunoglobulins
- Mice
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction
- Receptors, Antigen