Article
On the evolution of redundancy in genetic codes.
Journal of molecular evolution - 1 Jan 2000
Ardell D H, Sella G
Abstract excerpt
We simulate a deterministic population genetic model for the coevolution of genetic codes and protein-coding genes. We use very simple assumptions about translation, mutation, and protein fitness to calculate mutation-selection equilibria of codon frequencies and fitness in a large asexual population with a given genetic code. We then compute the fitnesses of altered genetic codes that compete to invade the...
Topics
- Codon
- Computer Simulation
- Evolution, Molecular
- Genetic Code
- Models, Genetic
- Mutation
- Mutation, Missense
- Selection, Genetic