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Article

Two independent mutational events in the loss of urate oxidase during hominoid evolution.

Journal of molecular evolution - 1 Jan 1992

Wu X W, Muzny D M, Lee C C, Caskey C T

Abstract excerpt

Urate oxidase was lost in hominoids during primate evolution. The mechanism and biological reason for this loss remain unknown. In an attempt to address these questions, we analyzed the sequence of urate oxidase genes from four species of hominoids: human (Homo sapiens), chimpanzee (Pan troglodytes), orangutan (Pongo pygmaeus), and gibbon (Hylobates). Two nonsense mutations at codon positions 33 and 187 and an...

Topics

Amino Acid Sequence
Animals
Base Sequence
Biological Evolution
Chromosome Deletion
DNA
Hominidae
Humans
Hylobates
Molecular Sequence Data
Mutation
Pan troglodytes

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Phylogeny

Polymerase Chain Reaction

Pongo pygmaeus

Urate Oxidase

Source

Identifiers

PMID: 1556746
DOI: 10.1007/BF00163854

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1556746-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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