Article
Molecular evolution of the urate oxidase-encoding gene in hominoid primates: nonsense mutations.
Gene - 30 Dec 1991
Yeldandi A V, Yeldandi V, Kumar S, Murthy C V, Wang X D, Alvares K, Rao M S, Reddy J K
Abstract excerpt
Nucleotide sequences of portions of second and fifth exons of urate oxidase encoding gene (UOX) of chimpanzee, gorilla, orangutan, rhesus monkey and squirrel monkey obtained following amplification by polymerase chain reaction have been compared with corresponding sequences of human, baboon and rat UOX. Two or more nonsense mutations are found in the coding regions of this UOX gene thus far analyzed in human,...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Biological Evolution
- Cercopithecinae
- Codon
- Exons
- Hominidae
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction