Article
Phosphorylation of HDM2 by Akt.
Oncogene - 27 Mar 2002
Ashcroft Margaret, Ludwig Robert L, Woods Douglas B, Copeland Terry D, Weber H Oliver, MacRae Elizabeth J, Vousden Karen H
Abstract excerpt
The HDM2 protein is a key regulator of the tumour suppressor, p53. Control of HDM2 function is critical for normal cell proliferation and stress responses, and it is becoming evident that multiple modifications of HDM2 can regulate its function within cells. In this study we show that HDM2 associated with the serine-threonine kinase, Akt, in response to growth factor stimulation of human primary cells. This...
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