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Article

Protein kinase D1 autophosphorylation via distinct mechanisms at Ser744/Ser748 and Ser916.

The Journal of biological chemistry - 23 Jan 2009

Rybin Vitalyi O, Guo Jianfen, Steinberg Susan F

Abstract excerpt

Protein kinase D1 (PKD1) is a physiologically important signaling enzyme that is activated via protein kinase C-dependent trans-phosphorylation of the activation loop at Ser744 and Ser748 followed by PKD1 autophosphorylation at Ser916. Although PKD-Ser916 autophosphorylation is widely used to track cellular PKD activity, this study exposes conditions leading to increased PKD-Ser(P)916 immunoreactivity without an...

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Source

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Identifiers

PMID: 19029298
DOI: 10.1074/jbc.M806381200
PMCID: PMC2629118

Genes

PKD1

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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