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Article

Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus.

Metabolism: clinical and experimental - 1 Jul 2007

Hiromine Yoshihisa, Ikegami Hiroshi, Fujisawa Tomomi, Nojima Koji, Kawabata Yumiko, Noso Shinsuke, Asano Katsuaki, Fukai Aya, Ogihara Toshio

Abstract excerpt

Multiple genes are involved in conferring susceptibility to autoimmune type 1 diabetes mellitus. The immunoreceptor programmed cell death-1 (PDCD-1), an inhibitory costimulatory molecule regulating peripheral tolerance, is reported to play an important role in the development of type 1 diabetes m...

Read the complete abstract on PubMed

Topics

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Share to Antigens, CD
Share to Apoptosis Regulatory Proteins
Share to Diabetes Mellitus, Type 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, MHC Class II

Share to Genetic Predisposition to Disease

Share to Polymorphism, Single Nucleotide

Share to Programmed Cell Death 1 Receptor

Share to Trinucleotide Repeats

Source

Identifiers

PMID: 17570250
DOI: 10.1016/j.metabol.2007.01.021

Genes

PDCD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17570250-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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Trinucleotide repeats of programmed cell death-1 gene are associated with susceptibility to type 1 diabetes mellitus.PMID 17570250Read ↗

Molecular scanning of the gene for programmed cell death-1 (PDCD-1) as a candidate for type 1 diabetes susceptibility.Semantic proximity Read ↗

PD-1 gene haplotype is associated with the development of type 1 diabetes mellitus in Japanese children.Semantic proximity Read ↗

Association of a putative regulatory polymorphism in the PD-1 gene with susceptibility to type 1 diabetes.Semantic proximity Read ↗

Low programmed cell death-1 (PD-1) expression in peripheral CD4(+) T cells in Japanese patients with autoimmune type 1 diabetes.Semantic proximity Read ↗

Association of PD-1 and PD-L1 Genetic Polymorphyisms with Type 1 Diabetes SusceptibilitySemantic proximity Read ↗

Association of PD-1 gene polymorphisms and serum soluble PD-1 levels with type 1 diabetes mellitus susceptibility in a Chinese Han cohort: a case-control study.Semantic proximity Read ↗

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Meta-analysis of genetic polymorphisms in programmed cell death 1. Associations with rheumatoid arthritis, ankylosing spondylitis, and type 1 diabetes susceptibility.Semantic proximity Read ↗

PDCD1 single nucleotide genes polymorphisms confer susceptibility to juvenile-onset systemic lupus erythematosus.Semantic proximity Read ↗

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