Article
HLA-Cw7 zygosity affects the size of a subset of CD158b+ natural killer cells.
Journal of clinical immunology - 1 Jan 2002
Husain Zaheed, Levitan Edward, Larsen Charles E, Mirza Nadeem M, Younes Souhad, Yunis Edmond J, Alper Chester A, Dubey Devendra P
Abstract excerpt
Individuals with certain HLA class I genotypes are highly susceptible to disease after viral infection. Natural killer (NK) cells kill virus-infected cells through a mechanism involving HLA class I receptors. These facts may be connected if an individual's HLA genotype regulates the number and function of NK cells. We have observed that subjects homozygous for the HLA-B/C region of conserved major...
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