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Article

Conformational strain in the hydrophobic core and its implications for protein folding and design.

Nature structural biology - 1 Jun 2002

Ventura Salvador, Vega Maria Cristina, Lacroix Emmanuel, Angrand Isabelle, Spagnolo Laura, Serrano Luis

Abstract excerpt

We have designed de novo 13 divergent spectrin SH3 core sequences to determine their folding properties. Kinetic analysis of the variants with stability similar to that of the wild type protein shows accelerated unfolding and refolding rates compatible with a preferential stabilization of the tra...

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Source

Identifiers

PMID: 12006985
DOI: 10.1038/nsb799

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-12006985-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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