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Article

Calculation of mutational free energy changes in transition states for protein folding.

Biophysical journal - 1 Aug 2003

Lindorff-Larsen Kresten, Paci Emanuele, Serrano Luis, Dobson Christopher M, Vendruscolo Michele

Abstract excerpt

Recent advances in experimental and computational methods have made it possible to determine with considerable accuracy the structures whose formation is rate limiting for the folding of some small proteins-the transition state ensemble, or TSE. We present a method to analyze and validate all-atom models of such structures. The method is based on the comparison of experimental data with the computation of the...

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Identifiers

PMID: 12885664
DOI: 10.1016/S0006-3495(03)74556-1
PMCID: PMC1303238

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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