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Article

Hydrophobic core packing in the SH3 domain folding transition state.

Nature structural biology - 1 Feb 2002

Northey Julian G B, Di Nardo Ariel A, Davidson Alan R

Abstract excerpt

How tightly packed is the hydrophobic core of a folding transition state structure? We have addressed this question by characterizing the effects on folding kinetics of > 40 substitutions of both large and small amino acids in the hydrophobic core of the Fyn SH3 domain. Our results show that residues at three positions, which we designate as the 'core folding nucleus', are tightly packed in the transition state,...

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Identifiers

PMID: 11786916
DOI: 10.1038/nsb748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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