Article
Early and aggressive treatment of rheumatoid arthritis patients affects the association of HLA class II antigens with progression of joint damage.
Arthritis and rheumatism - 1 Apr 2002
Lard L R, Boers M, Verhoeven A, Vos K, Visser H, Hazes J M W, Zwinderman A H, Schreuder G M T, Breedveld F C, De Vries R R P, van der Linden S, Zanelli E, Huizinga T W J
Abstract excerpt
OBJECTIVE: The presence of certain HLA class II antigens is strongly associated with the progression of joint destruction in rheumatoid arthritis (RA). Such antigens may be more effective than other class II antigens in inducing the formation of autoreactive T cells after presentation of (auto)antigens. We investigated whether early and aggressive treatment with disease-modifying antirheumatic drugs could modify...
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