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New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineages

12 Apr 2018

Abstract excerpt

The insertion Sequence IS6110, only present in the pathogens of the Mycobacterium tuberculosis Complex (MTBC), has been the gold-standard epidemiological marker for TB for more than 25 years, but biological implications of IS6110 transposition during MTBC adaptation to humans remain elusive. By studying 2,236 clinical isolates typed by IS6110-RFLP and covering the MTBC, we remarked a lineage-specific content of...

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PMID: 29649213
DOI: 10.1371/journal.pgen.1007282

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New insights into the transposition mechanisms of IS6110 and its dynamic distribution between Mycobacterium tuberculosis Complex lineagesPMID 29649213Read ↗

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IS <i>6110</i> , a <i>Mycobacterium tuberculosis</i> Complex-Specific Insertion Sequence, Is Also Present in the Genome of <i>Mycobacterium smegmatis</i> , Suggestive of Lateral Gene Transfer among Mycobacterial SpeciesSemantic proximity Read ↗

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