Article
Mutational screening of patients with nonalcoholic chronic pancreatitis: identification of further trypsinogen variants.
The American journal of gastroenterology - 1 Feb 2002
Teich Niels, Bauer Nadine, Mössner Joachim, Keim Volker
Abstract excerpt
OBJECTIVES: Mutations of the cationic trypsinogen (CT) and the serine protease inhibitor, Kazal type 1 (SPINK 1) are associated with chronic pancreatitis. After mutational screening of a cohort of patients with nonalcoholic chronic pancreatitis, we report three novel variants of the trypsinogen molecule and the clinical characteristics of the carriers. METHODS: The coding region of the exon 2 and 3 of the CT gene...
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