Article
The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis.
Digestive diseases and sciences - 1 Mar 2011
Gasiorowska Anita, Talar-Wojnarowska Renata, Czupryniak Leszek, Smolarz Beata, Romanowicz-Makowska Hanna, Kulig Andrzej, Malecka-Panas Ewa
Abstract excerpt
BACKGROUND: The main cause of chronic pancreatitis (CP) is excessive alcohol consumption. On the other hand, only 5-10% of heavy drinkers develop chronic pancreatitis. We have only limited information regarding the pathogenic mechanism by which alcohol leads to the disease. Mutations of the PRSS1 and SPINK 1 have been mostly implicated in hereditary and idiopathic CP, but their presence in other types of this...
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