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Article

Pro- and anticoagulant properties of factor V in pathogenesis of thrombosis and bleeding disorders.

International journal of laboratory hematology - 1 May 2016

Dahlbäck Björn

Abstract excerpt

Factor V (FV) serves an important role in the regulation of blood coagulation, having both pro- and anticoagulant properties. The circulating high molecular weight single-chain FV molecule undergoes a series of proteolytic cleavages during both activation of coagulation and during anticoagulant regulation of coagulation by activated protein C (APC). It is noteworthy that mutations in the factor V gene (F5) either...

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Source

Identifiers

PMID: 27161771
DOI: 10.1111/ijlh.12508

Genes

APC
TFPI

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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