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Article

Increased expression of CHK2 in human gastric carcinomas harboring p53 mutations.

International journal of cancer - 1 May 2002

Shigeishi Hideo, Yokozaki Hiroshi, Oue Naohide, Kuniyasu Hiroki, Kondo Tomohiro, Ishikawa Takenori, Yasui Wataru

Abstract excerpt

Human Chk1 and Chk2 are DNA damage-activated protein kinases that function as downstream mediators of ataxia-telangiectasia mutated (ATM), which is involved in G(2)/M cell cycle arrest. To clarify the relation between the expression of Chk1/Chk2 and p53 gene status in human gastric carcinomas, we examined expression of Chk1, Chk2 and p53 proteins in 87 gastric carcinomas by Western blotting and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11948492
DOI: 10.1002/ijc.10272

Genes

ATM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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