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Article

Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo.

Oncogene - 24 Aug 2000

Ge N L, Rudikoff S

Abstract excerpt

Biochemical abnormalities associated with the development of multiple myeloma have been difficult to define especially in terms of demonstrating an in vivo effect of suspected lesions. Herein, we have identified such a defect associated with lack of expression of PTEN, a cellular phosphatase involved in the regulation of phosphatidylinositol phosphates (PIP's). In myeloma cells, PIP's are required for...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 10962569
DOI: 10.1038/sj.onc.1203801

Genes

PTEN
PIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Expression of PTEN in PTEN-deficient multiple myeloma cells abolishes tumor growth in vivo.PMID 10962569Read ↗

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Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival.Semantic proximity Read ↗

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