Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.

The Journal of biological chemistry - 21 Jun 2002

Schreiber Valérie, Amé Jean-Christophe, Dollé Pascal, Schultz Inès, Rinaldi Bruno, Fraulob Valérie, Ménissier-de Murcia Josiane, de Murcia Gilbert

Abstract excerpt

The DNA damage dependence of poly(ADP-ribose) polymerase-2 (PARP-2) activity is suggestive of its implication in genome surveillance and protection. Here we show that the PARP-2 gene, mainly expressed in actively dividing tissues follows, but to a smaller extent, that of PARP-1 during mouse development. We found that PARP-2 and PARP-1 homo- and heterodimerize; the interacting interfaces, sites of reciprocal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alkylating Agents
Share to Comet Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Ligase ATP

Share to DNA Ligases

Share to DNA Polymerase beta

Share to Methylnitrosourea

Share to Poly-ADP-Ribose Binding Proteins

Share to Poly(ADP-ribose) Polymerases

Source

Identifiers

PMID: 11948190
DOI: 10.1074/jbc.M202390200

Genes

XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Poly(ADP-ribose) polymerase-2 (PARP-2) is required for efficient base excision DNA repair in association with PARP-1 and XRCC1.PMID 11948190Read ↗

Phenotypic characterization of Parp-1 and Parp-2 deficient mice and cells.Semantic proximity Read ↗

PARP-2 domain requirements for DNA damage-dependent activation and localization to sites of DNA damageSemantic proximity Read ↗

Involvement of poly(ADP-ribose) polymerase in base excision repair.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase-1: what have we learned from the deficient mouse model?Semantic proximity Read ↗

Poly(ADP-ribose) polymerase is hyperactivated in homologous recombination-defective cells.Semantic proximity Read ↗

DNA strand break-sensing molecule poly(ADP-Ribose) polymerase cooperates with p53 in telomere function, chromosome stability, and tumor suppression.Semantic proximity Read ↗

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1Semantic proximity Read ↗

Requirement of poly(ADP-ribose) polymerase in recovery from DNA damage in mice and in cells.Semantic proximity Read ↗

Epigenetic remodeling during UV exposure: high resolution analysis of histone post-translational modifications in a DNA binding protein 2 mutant model.Semantic proximity Read ↗

Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not CenpcSemantic proximity Read ↗

Poly(ADP-ribose) polymerase-1 antagonizes DNA resection at double-strand breaksSemantic proximity Read ↗

Distinct roles for PARP-1 and PARP-2 in c-Myc–driven B-cell lymphoma in miceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.