Article
Correct integration mediated by integrase-LexA fusion proteins incorporated into HIV-1.
Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2002
Holmes-Son Michelle L, Chow Samson A
Abstract excerpt
Fusion of wild-type or truncated integrase to a sequence-specific DNA-binding protein, such as the Escherichia coli LexA repressor, results in an integration bias toward the recognition site of the DNA-binding protein in vitro. Integrase-defective HIV-1 could become integration-competent by supplying the fusion protein in trans. To understand the mechanism of complementation, the virus-host DNA junctions of cells...
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