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Article

Complementation of integrase function in HIV-1 virions.

The EMBO journal - 15 Aug 1997

Fletcher T M, Soares M A, McPhearson S, Hui H, Wiskerchen M, Muesing M A, Shaw G M, Leavitt A D, Boeke J D, Hahn B H

Abstract excerpt

Proviral integration is essential for HIV-1 replication and represents an important potential target for antiviral drug design. Although much is known about the integration process from studies of purified integrase (IN) protein and synthetic target DNA, provirus formation in virally infected cells remains incompletely understood since reconstituted in vitro assays do not fully reproduce in vivo integration...

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Identifiers

PMID: 9305653
DOI: 10.1093/emboj/16.16.5123
PMCID: PMC1170146

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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