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Article

Targeting human immunodeficiency virus (HIV) type 2 integrase protein into HIV type 1.

Journal of virology - 1 Oct 1999

Liu H, Wu X, Xiao H, Kappes J C

Abstract excerpt

Integrase (IN) is the only retroviral enzyme necessary for the integration of retroviral cDNA into the host cell's chromosomes. The structure and function of IN is highly conserved. The human immunodeficiency virus type 2 (HIV-2) IN has been shown to efficiently support 3' processing and strand transfer of HIV-1 DNA substrate in vitro. To determine whether HIV-2 IN protein (IN(2)) could substitute for HIV-1 IN...

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Share to DNA, Complementary
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 10482639
DOI: 10.1128/JVI.73.10.8831-8836.1999
PMCID: PMC112906

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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