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Plasmid-Mediated Quinolone Resistance

19 Sept 2014

Abstract excerpt

Three mechanisms for plasmid-mediated quinolone resistance (PMQR) have been discovered since 1998. Plasmid genes qnrA, qnrB, qnrC, qnrD, qnrS, and qnrVC code for proteins of the pentapeptide repeat family that protects DNA gyrase and topoisomerase IV from quinolone inhibition. The qnr genes appear to have been acquired from chromosomal genes in aquatic bacteria, are usually associated with mobilizing or...

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PMID: 25584197
DOI: 10.1128/microbiolspec.plas-0006-2013

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