Interaction of plasmid and host quinolone resistance

Abstract excerpt

Sir, Resistance to quinolones in Gram-negative bacteria is usually caused by chromosomal mutations that alter the target enzymes DNA gyrase and topoisomerase IV or activate the efflux systems that pump the drugs out of the cytoplasm. Loss of porin channels for drug entry may also contribute to resistance, but is less important. Plasmid-mediated quinolone resistance, long thought not to exist, has recently been...

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