The yeast med1 mutant undergoes both meiotic homolog nondisjunction and precocious separation of sister chromatids.

doi:10.1093/genetics/136.1.65

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Article

The yeast med1 mutant undergoes both meiotic homolog nondisjunction and precocious separation of sister chromatids.

Genetics - 1 Jan 1994

Rockmill B, Roeder G S

Abstract excerpt

A mutant at the yeast MED1 locus was isolated in a screen for sporulation-proficient, meiotic-lethal mutants. Synaptonemal complex formation in the med1 mutant is apparently normal and med1 strains undergo meiotic crossing over at approximately 50% of the wild-type level. The med1 mutant undergoes homolog nondisjunction at meiosis I, presumably as a consequence of the decrease in crossing over. In addition, the...

Topics

Cell Nucleus
Chromatids
Copper
Crossing Over, Genetic
Gene Conversion
Genes, Fungal
Genes, Lethal
Genetic Complementation Test
Genetic Markers
Genotype
Meiosis
Microscopy, Electron

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutagenesis

Nondisjunction, Genetic

Recombination, Genetic

Saccharomyces cerevisiae

Spores, Fungal

Synaptonemal Complex

Source

Open in PubMed Open full text

Identifiers

PMID: 8138177
DOI: 10.1093/genetics/136.1.65
PMCID: PMC1205793

Genes

MED1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8138177-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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