Article
Sex-dependent genetic markers of CYP3A4 expression and activity in human liver microsomes.
Pharmacogenomics - 1 May 2007
Schirmer Markus, Rosenberger Albert, Klein Kathrin, Kulle Bettina, Toliat Mohammad R, Nürnberg Peter, Zanger Ulrich M, Wojnowski Leszek
Abstract excerpt
OBJECTIVE: To find genetic markers of the individual cytochrome P450 (CYP)3A expression. METHODS: A large collection of liver samples phenotyped for CYP3A expression and activity was genotyped for CYP3A variants. Data were analyzed for associations between CYP3A phenotypes and genotypes, and for...
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