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Article

Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.

Science (New York, N.Y.) - 26 Apr 2002

Stevens Jennitte L, Cantin Greg T, Wang Gang, Shevchenko Andrej, Shevchenko Anna, Berk Arnold J

Abstract excerpt

Sur2 is a metazoan Mediator subunit that interacts with the adenovirus E1A protein and functions in a mitogen-activated protein kinase pathway required for vulva development in Caenorhabditis elegans. We generated sur2-/- embryonic stem cells to analyze its function as a mammalian Mediator component. Our results show that Sur2 forms a subcomplex of the Mediator with two other subunits, TRAP/Med100 and 95....

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Share to Adenovirus E1A Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to ets-Domain Protein Elk-1

Share to Genes, Immediate-Early

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Source

Identifiers

PMID: 11934987
DOI: 10.1126/science.1068943

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Transcription control by E1A and MAP kinase pathway via Sur2 mediator subunit.PMID 11934987Read ↗

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sur-2, a novel gene, functions late in the let-60 ras-mediated signaling pathway during Caenorhabditis elegans vulval induction.Semantic proximity Read ↗

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