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Article

Ras induces mediator complex exchange on C/EBP beta.

Molecular cell - 30 Jan 2004

Mo Xianming, Kowenz-Leutz Elisabeth, Xu Hong, Leutz Achim

Abstract excerpt

C/EBPbeta is an intrinsically repressed transcription factor that regulates genes involved in differentiation, proliferation, tumorigenesis, and apoptosis. C/EBPbeta acts as a repressor that is turned into an activator by the Ras oncoprotein through phosphorylation of a MAPK site. C/EBPbeta activation is accompanied by a conformational change. Active and repressive C/EBPbeta interacts with multisubunit Mediator...

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Source

Identifiers

PMID: 14759369
DOI: 10.1016/s1097-2765(03)00521-5

Genes

CDK8
EBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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