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Article

Genetics of osteonecrosis in children and adults with systemic lupus erythematosus.

Rheumatology (Oxford, England) - 1 Sept 2023

Webber Declan, Cao Jingjing, Dominguez Daniela, Gladman Dafna D, Knight Andrea, Levy Deborah M, Liao Fangming, Ng Lawrence, Paterson Andrew D, Touma Zahi, Wither Joan, Urowitz Murray, Silverman Earl D, Hiraki Linda T

Abstract excerpt

OBJECTIVES: Genetics plays an important role in SLE risk, as well as osteonecrosis (ON), a significant and often debilitating complication of SLE. We aimed to identify genetic risk loci for ON in people with childhood-onset (cSLE) and adult-onset (aSLE) SLE. METHODS: We enrolled participants from two tertiary care centres who met classification criteria for SLE. Participants had prospectively collected clinical...

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PMID: 36651668
DOI: 10.1093/rheumatology/kead016

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