Article
Genetic variability in insulin action inhibitor Ikkbeta (IKBKB) does not play a major role in the development of type 2 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Apr 2002
Menzaghi Claudia, Plengvidhya Nattachet, Ma Xiaowei, Warram James H, Shoelson Steven E, Doria Alessandro
Abstract excerpt
Recent evidence indicates that IkappaB kinase beta (Ikkbeta) may be a mediator of acquired forms of insulin-resistance. In this study, we examined whether genetic variability at the Ikkbeta locus (IKBKB) contributes to the development of genetic forms of early-onset type 2 diabetes transmitted with an autosomal dominant mode of inheritance. Linkage with four markers flanking the IKBKB gene was evaluated in 32...
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