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Article

Alterations of beta-catenin pathway in non-melanoma skin tumors: loss of alpha-ABC nuclear reactivity correlates with the presence of beta-catenin gene mutation.

The American journal of pathology - 1 Dec 2003

Doglioni Claudio, Piccinin Sara, Demontis Silvia, Cangi Maria Giulia, Pecciarini Lorenza, Chiarelli Concetta, Armellin Michela, Vukosavljevic Tamara, Boiocchi Mauro, Maestro Roberta

Abstract excerpt

To determine the role of beta-catenin pathway in human skin carcinogenesis, 135 non-melanoma skin tumors were analyzed for beta-catenin expression and gene mutations. Intense nucleo-cytoplasmic immunoreactivity for C terminus beta-catenin antibodies was observed in all pilomatricomas and in single cases of trichoepithelioma and squamous cell carcinoma showing peculiar signs of matrical differentiation. Moderate...

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Identifiers

PMID: 14633602
DOI: 10.1016/s0002-9440(10)63585-7
PMCID: PMC1892405

Genes

MITF
APC
AXIN2

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