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Article

Role of medium- and long-range interactions to the stability of the mutants of T4 lysozyme.

Preparative biochemistry & biotechnology - 1 Aug 2001

Gromiha M M, Thangakani A M

Abstract excerpt

Inter-residue interactions play an important role to the folding and stability of protein molecules. In this work, we analyze the role of medium- and long-range interactions to the stability of T4 lysozyme mutants. We found that, in buried mutations, the increase in long-range contacts upon mutations destabilizes the protein, whereas, in surface mutations, the increase in long-range contacts increases the...

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PMID: 11513088
DOI: 10.1081/PB-100104905

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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