Article
Levels of circumsporozoite protein in the Plasmodium oocyst determine sporozoite morphology.
The EMBO journal - 2 Apr 2002
Thathy Vandana, Fujioka Hisashi, Gantt Soren, Nussenzweig Ruth, Nussenzweig Victor, Ménard Robert
Abstract excerpt
The sporozoite stage of the Plasmodium parasite is formed by budding from a multinucleate oocyst in the mosquito midgut. During their life, sporozoites must infect the salivary glands of the mosquito vector and the liver of the mammalian host; both events depend on the major sporozoite surface protein, the circumsporozoite protein (CS). We previously reported that Plasmodium berghei oocysts in which the CS gene...
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