Isl1-expressing non-venous cell lineage contributes to cardiac lymphatic vessel development

Abstract excerpt

The origin of the mammalian lymphatic vasculature has been studied for more than a century; however, details regarding organ-specific lymphatic development remain unknown. A recent study reported that cardiac lymphatic endothelial cells (LECs) stem from venous and non-venous origins in mice. Here, we identified Isl1 -expressing progenitors as a potential non-venous origin of cardiac LECs. Genetic lineage tracing...

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