Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.

Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 2002

Hong Young-Kwon, Harvey Natasha, Noh Yun-Hee, Schacht Vivien, Hirakawa Satoshi, Detmar Michael, Oliver Guillermo

Abstract excerpt

Early during development, one of the first indications that lymphangiogenesis has begun is the polarized expression of the homeobox gene Prox1 in a subpopulation of venous endothelial cells. It has been shown previously that Prox1 expression in the cardinal vein promotes and maintains the budding of endothelial cells that will form the lymphatic vascular system. Prox1-deficient mice are devoid of lymphatic...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Endothelium, Vascular
Share to Gene Expression Regulation, Developmental

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glycoproteins

Share to Homeodomain Proteins

Share to Lymphatic System

Share to Microcirculation

Share to Tumor Suppressor Proteins

Share to Vesicular Transport Proteins

Source

Identifiers

PMID: 12412020
DOI: 10.1002/dvdy.10163

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prox1 is a master control gene in the program specifying lymphatic endothelial cell fate.PMID 12412020Read ↗

Prox1, master regulator of the lymphatic vasculature phenotype.Semantic proximity Read ↗

An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype.Semantic proximity Read ↗

Embryonic vascular endothelial cells are malleable to reprogramming via Prox1 to a lymphatic gene signatureSemantic proximity Read ↗

Divergence of zebrafish and mouse lymphatic cell fate specification pathways.Semantic proximity Read ↗

Prox1 expression is negatively regulated by miR-181 in endothelial cellsSemantic proximity Read ↗

Lymphatic endothelial cell identity is reversible and its maintenance requires Prox1 activity.Semantic proximity Read ↗

Single‐cell analysis of lymphatic endothelial cell fate specification and differentiation during zebrafish developmentSemantic proximity Read ↗

Identification of targets of Prox1 during in vitro vascular differentiation from embryonic stem cells: functional roles of HoxD8 in lymphangiogenesisSemantic proximity Read ↗

Notch1 functions as a negative regulator of lymphatic endothelial cell differentiation in the venous endothelium.Semantic proximity Read ↗

Prox1 Function Is Required for the Development of the Murine Lymphatic SystemSemantic proximity Read ↗

Prox1 Induces Lymphatic Endothelial Differentiation via Integrin α9 and Other Signaling CascadesSemantic proximity Read ↗

Lymphatic endothelial reprogramming of vascular endothelial cells by the Prox-1 homeobox transcription factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.